Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM

• Miyake, Yuka

• Ishikawa, Syungo

• Kimura, Yu

• Son, Aoi

• Imai, Hirohiko

• Matsuda, Tetsuya

• Yamada, Hisatsugu

• Toshimitsu, Akio

• Kondo, Teruyuki

抄録

Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo.

収録刊行物

• Sensors

  Sensors 15 (12), 31973-31986, 2015-12-18

  MDPI

キーワード

• chiral dendrimer
• gadolinium
• contrast agent
• magnetic resonance imaging (MRI)
• quartz crystal microbalance (QCM)
• association constant (Ka)

詳細情報

• CRID: 1050007750000671104
• NII論文ID: 120007141563
• ISSN: 14248220
• DOI: 10.3390/s151229900
• HANDLE: 2433/210694
• Web Site: http://repo.lib.tokushima-u.ac.jp/115725
• Web Site: http://www.mdpi.com/1424-8220/15/12/29900/pdf
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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