Multicomponent Synthesis of Imidazo[1,2-a]pyridines: Aerobic Oxidative Formation of C–N and C–S Bonds by Flavin–Iodine-Coupled Organocatalysis

• Okai, Hayaki

• Tanimoto, Kazumasa

• Ohkado, Ryoma

• Iida, Hiroki

抄録

Herein, we report an aerobic oxidative C–N bond-forming process that enables the facile synthesis of imidazo[1,2-a]pyridines and takes advantage of a coupled organocatalytic system that uses flavin and iodine. Furthermore, the dual catalytic system can be applied to the one-pot, three-step synthesis of 3-thioimidazo[1,2-a]pyridines from aminopyridines, ketones, and thiols.

収録刊行物

• Organic Letters

  Organic Letters 22 (20), 8002-8006, 2020-10-16

  American Chemical Society

キーワード

• Flavins
• Chemical synthesis
• Catalysts
• Oxygen
• Catalytic reactions

詳細情報

• CRID: 1050852724601381760
• NII論文ID: 120007161476
• ISSN: 15237060
• ISSN: 15237052
• DOI: 10.1021/acs.orglett.0c02929
• Web Site: http://ir.lib.shimane-u.ac.jp/53851
• Web Site: https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c02929
• 本文言語コード: en
• 資料種別: journal article
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