Self-healing polyurethane elastomers based on charge-transfer interactions for biomedical applications

• Imato, Keiichi

• Nakajima, Hidekazu

• Yamanaka, Ryota

• Takeda, Naoya

Abstract

One promising application of self-healing polymeric materials is biomedical use. Although charge-transfer (CT) interactions have been employed to construct self-healing polymers as well as other reversible bonds and interactions, their potential for biomedical applications has never been investigated. In this study, we fabricated self-healable and cell-compatible polyurethane elastomers cross-linked by CT complexes between electron-rich pyrene (Py) and electron-deficient naphthalene diimide (NDI) by simply blending two linear polymers with Py or NDI as a repeating unit. The elastomers with different blend ratios self-healed damage over 1 day in mild conditions, including in air and water at 30–100 °C. The mechanical properties of damaged elastomers were almost restored after healing in air at 100 °C, and even in air at 30 °C and in water at 70 °C, healing was also possible to a certain extent. The good cell compatibility of the polyurethane elastomers was demonstrated by culturing two kinds of cells on the thin film substrates.

Journal

• Polymer Journal

  Polymer Journal 53 355-362, 2020-10-22

  Springer Nature

Keywords

• biomaterial
• cell culture scaffold
• charge-transfer interaction
• elastomer
• selfhealing
• supramolecular chemistry

Details

• CRID: 1050014791007246080
• NII Article ID: 120007168961
• DOI: 10.1038/s41428-020-00432-4
• ISSN: 13490540
• ISSN: 00323896
• Web Site: http://ir.lib.hiroshima-u.ac.jp/00051511
• Web Site: https://www.nature.com/articles/s41428-020-00432-4.pdf
• Web Site: https://www.nature.com/articles/s41428-020-00432-4
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN