The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection

• Ohigashi, Izumi

• Frantzeskakis, Melina

• Jacques, Alison

• Fujimori, Sayumi

• Ushio, Aya

• Yamashita, Fusano

• Ishimaru, Naozumi

• Yin, Da

• Cam, Margaret

• Kelly, Michael C.

• Awasthi, Parirokh

• Takada, Kensuke

• Takahama, Yousuke

書誌事項

タイトル別名

• β5t shapes CD8 T cells without negative selection

抄録

The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus.

収録刊行物

• Journal of Experimental Medicine

  Journal of Experimental Medicine 218 (4), e20201904-, 2021-02-08

  Rockefeller University Press

キーワード

• Immunology
• Immunology and Allergy

詳細情報

• CRID: 1050290163813670528
• NII論文ID: 120007170553
• NII書誌ID: AA00697559
• ISSN: 00221007
• ISSN: 15409538
• DOI: 10.1084/jem.20201904
• Web Site: http://repo.lib.tokushima-u.ac.jp/116455
• Web Site: https://rupress.org/jem/article-pdf/doi/10.1084/jem.20201904/1832795/jem_20201904.pdf
• 本文言語コード: en
• 資料種別: journal article
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