Kit-independent mast cell adhesion mediated by Notch

• 村田, 暁彦

• 吉野, 三也

• 林, 眞一

• Hikosaka, Mari

• Zhou, Lan

抄録

Kit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by Notch family members. On stromal cells transduced with each Notch ligand gene, Kit and its signaling become dispensable for the entire adhesion process of MCs from tethering to spreading. The Notch-mediated spreading of adherent MCs involves the activation of signaling via phosphatidylinositol 3-kinases and mitogen-activated protein kinases, similar to Kit-mediated spreading. Despite the activation of the same signaling pathways, while Kit supports the adhesion and survival of MCs, Notch only supports adhesion. Thus, Notch family members are specialized adhesion molecules for MCs that effectively replace the adhesion function of Kit in order to support the interaction of MCs with the surrounding cellular microenvironments.

収録刊行物

• INTERNATIONAL IMMUNOLOGY

  INTERNATIONAL IMMUNOLOGY 31 (2), 69-79, 2019-02

  Oxford University Press

キーワード

• Delta-like
• Jagged

詳細情報

• CRID: 1050296829526900096
• NII論文ID: 120007170663
• ISSN: 09538178
• ISSN: 14602377
• DOI: 10.1093/intimm/dxy067
• Web Site: https://repository.lib.tottori-u.ac.jp/records/7213
• Web Site: http://academic.oup.com/intimm/article-pdf/31/2/69/40544011/intimm_31_2_69.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020189486
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN