Solid‐State Radical C−H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials

• Pang, Yadong

• Lee, Joo Won

• Kubota, Koji

• Ito, Hajime

書誌事項

タイトル別名

• Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials

抄録

The application of piezoelectricity for the generation of trifluoromethyl (CF3) radicals is reported together with the development of a method for the mechanochemical C-H trifluoromethylation of aromatic compounds. As compared to conventional solution-based approaches, this mechanoredox C-H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N-heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science.

収録刊行物

• Angewandte chemie-international edition

  Angewandte chemie-international edition 59 (50), 22570-22576, 2020-12-07

  Wiley-Blackwell

キーワード

• C-H trifluoromethylation
• mechanochemistry
• radical reactions
• solid-state reactions
• synthetic methods

詳細情報

• CRID: 1050853334096142848
• NII論文ID: 120007175161
• DOI: 10.1002/anie.202009844
• ISSN: 15213773
• ISSN: 14337851
• HANDLE: 2115/83448
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.202009844
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202009844
• Web Site: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.202009844
• Web Site: https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/anie.202009844
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN