Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

• Suzuki, Akinobu Z.

• Sakano, Taichi

• Sasaki, Hirona

• Watahiki, Rei

• Sone, Masaki

• Horikawa, Kazuki

• Furuta, Toshiaki

Abstract

We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.

Journal

• Chemical Communications

  Chemical Communications 57 (46), 5630-5633, 2021-05-21

  The Royal Society of Chemistry

Keywords

• Materials Chemistry
• Metals and Alloys
• Surfaces, Coatings and Films
• General Chemistry
• Ceramics and Composites
• Electronic, Optical and Magnetic Materials
• Catalysis

Details

• CRID: 1050290384133947904
• NII Article ID: 120007175419
• NII Book ID: AA11071130
• ISSN: 1364548X
• ISSN: 13597345
• DOI: 10.1039/d1cc01405f
• Web Site: http://repo.lib.tokushima-u.ac.jp/116515
• Web Site: http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC01405F
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN