Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core

• 黒瀬, 朋浩

• 塚野, 千尋

• 南條, 毅

• 竹本, 佳司

抄録

This report describes the total synthesis of the complex, oxygenated tetracyclic alkaloid, lyconesidine B. The key synthetic challenge involves diastereoselective generation of a decahydroquinoline ring with a quaternary carbon at the angular position via domino cyclopropanation, ring-opening, and reduction. Another crucial step is the domino ene-yne metathesis involving a quaternary ammonium ion, leading to the construction of a decahydroazaazulen framework.

収録刊行物

• Organic Letters

  Organic Letters 23 (3), 676-681, 2021-02

  American Chemical Society (ACS)

キーワード

• Catalysts
• Organic synthesis
• Organic compounds
• Cyclization
• Chemical synthesis

詳細情報

• CRID: 1050571948037518720
• NII論文ID: 120007177779
• ISSN: 15237052
• ISSN: 15237060
• HANDLE: 2433/266607
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles