Metabolomics-based engineering for biofuel and bio-based chemical production in microalgae and cyanobacteria: A review

• Kato, Yuichi

• Inabe, Kosuke

• Hidese, Ryota

• Kondo, Akihiko

• Hasunuma, Tomohisa

Abstract

Metabolomics, an essential tool in modern synthetic biology based on the design-build-test-learn platform, is useful for obtaining a detailed understanding of cellular metabolic mechanisms through comprehensive analyses of the metabolite pool size and its dynamic changes. Metabolomics is critical to the design of a rational metabolic engineering strategy by determining the rate-limiting reaction and assimilated carbon distribution in a biosynthetic pathway of interest. Microalgae and cyanobacteria are promising photosynthetic producers of biofuels and bio-based chemicals, with high potential for developing a bioeconomic society through bio-based carbon neutral manufacturing. Metabolomics technologies optimized for photosynthetic organisms have been developed and utilized in various microalgal and cyanobacterial species. This review provides a concise overview of recent achievements in photosynthetic metabolomics, emphasizing the importance of microalgal and cyanobacterial cell factories that satisfy industrial requirements.

Journal

• Bioresource Technology

  Bioresource Technology 344 126196-, 2022-01

  Elsevier

Keywords

• Photosynthetic metabolomics
• Microalgae
• Cyanobacteria
• Biofuel
• Bio-based chemicals

Details

• CRID: 1050295336680454784
• NII Article ID: 120007184289
• NII Book ID: AA10838373
• DOI: 10.1016/j.biortech.2021.126196
• ISSN: 18732976
• ISSN: 09608524
• HANDLE: 20.500.14094/90008932
• Web Site: https://api.elsevier.com/content/article/PII:S0960852421015388?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0960852421015388?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN