Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora

• Tsutsumi, Rie

• Yamasaki, Yuki

• Takeo, Jiro

• Miyahara, Hiroko

• Sebe, Mayu

• Bando, Masahiro

• Tanba, Yousuke

• Mishima, Yuna

• Takeji, Kana

• Ueshima, Nanako

• Kuroda, Masashi

• Masumoto, Saeko

• Harada, Nagakatsu

• Fukuda, Daiju

• Yoshimoto, Ryoko

• Tsutsumi, Yasuo M

• Aihara, Ken-ichi

• Sata, Masataka

• Sakaue, Hiroshi

Abstract

Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE−/− mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.

Journal

• Translational Research

  Translational Research 237 16-30, 2021-03-26

  Elsevier

Keywords

• Biochemistry (medical)
• Public Health, Environmental and Occupational Health
• General Medicine
• Physiology (medical)

Details

• CRID: 1050853796615473664
• NII Article ID: 120007185164
• NII Book ID: AA12149426
• ISSN: 19315244
• DOI: 10.1016/j.trsl.2021.03.016
• Web Site: http://repo.lib.tokushima-u.ac.jp/116689
• Web Site: https://api.elsevier.com/content/article/PII:S1931524421000797?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1931524421000797?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN