Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats

• Matsui, Saori

• Yoneda, Naomichi

• Maezono, Hazuki

• Kuremoto, Katsutaka

• Ishimoto, Takuya

• Nakano, Takayoshi

• Yumoto, Hiromichi

• Ebisu, Shigeyuki

• Noiri, Yuichiro

• Hayashi, Mikako

• Sompop Bencharit

  editor

抄録

Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats. Saori Matsui, et al. PLOS ONE. 2020.9(29) doi.org/10.1371/journal.pone.0239660

The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis.

収録刊行物

• PLoS ONE

  PLoS ONE 15 (9), e0239660-, 2020-09-29

  Public Library of Science

キーワード

• Multidisciplinary

詳細情報

• CRID: 1050018218946538112
• NII論文ID: 120007188421
• DOI: 10.1371/journal.pone.0239660
• ISSN: 19326203
• HANDLE: 11094/89799
• Web Site: http://repo.lib.tokushima-u.ac.jp/116623
• Web Site: https://dx.plos.org/10.1371/journal.pone.0239660
• 本文言語コード: en
• 資料種別: journal article
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