Dynamic surface-enhanced Raman spectroscopy of DNA oligomer with a single hotspot from a gold nanoparticle dimer

• Sugano, Koji

• Maruoka, Katsunari

• Ikegami, Kohei

• Uesugi, Akio

• Isono, Yoshitada

Abstract

Various nanostructures for single-molecule surface-enhanced Raman spectroscopy (SERS) have been fabricated through a random aggregation process using nanoparticles that can stochastically generate multiple hotspots in the laser spot. This leads to multiple molecule detection. In this study, a single gold nanoparticle (AuNP) dimer with a single hotspot was fabricated in a laser spot controlling the position and orientation on a silicon substrate using a nanotrench-guided self-assembly. The Raman peaks of deoxyribonucleic acid (DNA) were dynamically observed, indicating a single DNA oligomer detection composed of adenine, guanine, cytosine, phosphate, and deoxyribose.

Journal

• Optics Letters

  Optics Letters 47 (2), 373-376, 2022-01-15

  Optica Publishing Group

Keywords

• Atomic and Molecular Physics, and Optics

Details

• CRID: 1050295027687513088
• NII Article ID: 120007188915
• DOI: 10.1364/ol.441580
• ISSN: 15394794
• ISSN: 01469592
• HANDLE: 20.500.14094/90008983
• Web Site: https://opg.optica.org/viewmedia.cfm?URI=ol-47-2-373&seq=0
• Text Lang: en
• Article Type: journal article
• Data Source:
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  • Crossref
  • CiNii Articles
  • KAKEN