Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography

• Hsu, Destiny

• Kwon, Ji Hoon

• Ng, Ringo

• 巻田, 修一

• 安野, 嘉晃

• Sarunic, Marinko V.

• Ju, Myeong Jin

抄録

Retinal microvasculature and the retinal pigment epithelium (RPE) play vital roles in maintaining the health and metabolic activity of the eye. Visualization of these retina structures is essential for pre-clinical studies of vision-robbing diseases, such as age-related macular degeneration (AMD). We have developed a quantitative multi-contrast polarization diversity OCT and angiography (QMC-PD-OCTA) system for imaging and visualizing pigment in the RPE using degree of polarization uniformity (DOPU), along with flow in the retinal capillaries using OCT angiography (OCTA). An adaptive DOPU averaging kernel was developed to increase quantifiable values from visual data, and QMC en face images permit simultaneous visualization of vessel location, depth, melanin region thickness, and mean DOPU values, allowing rapid identification and differentiation of disease symptoms. The retina of five different mice strains were measured in vivo , with results demonstrating potential for pre-clinical studies of retinal disorders.

収録刊行物

• Biomedical Optics Express

  Biomedical Optics Express 11 (12), 6945-6961, 2020-12

  Optica Publishing Group

キーワード

• Atomic and Molecular Physics, and Optics
• Biotechnology

詳細情報

• CRID: 1050009640090998016
• NII論文ID: 120007192286
• DOI: 10.1364/boe.403209
• ISSN: 21567085
• HANDLE: 2241/0002002707
• Web Site: https://tsukuba.repo.nii.ac.jp/records/2002707
• Web Site: https://opg.optica.org/viewmedia.cfm?URI=boe-11-12-6945&seq=0
• 本文言語コード: en
• 資料種別: journal article
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