Identification of pulvomycin as an inhibitor of the futalosine pathway

• Ogasawara, Yasushi

• Umetsu, Shuhei

• Inahashi, Yuki

• Nonaka, Kenichi

• Dairi, Tohru

Abstract

Menaquinone is an essential cofactor in the electron-transfer pathway for bacteria. Menaquinone is biosynthesized from chorismate using either the well-known canonical pathway established by pioneering studies in model microorganisms or the futalosine pathway, which we discovered in Streptomyces. Because Helicobacter pylori, which causes stomach cancer, uses the futalosine pathway and most beneficial intestinal bacteria including lactobacilli use the canonical pathway, the futalosine pathway will be a great target to develop antibiotics specific for H. pylori. Here, we searched for such compounds from metabolites produced by actinomycetes and identified pulvomycin from culture broth of Streptomyces sp. K18-0194 as a specific inhibitor of the futalosine pathway.

Journal

• Journal of antibiotics

  Journal of antibiotics 74 825-829, 2021-08-20

  Springer Nature

Keywords

• Drug Discovery
• Pharmacology

Details

• CRID: 1050573243017424256
• NII Article ID: 120007193348
• DOI: 10.1038/s41429-021-00465-8
• ISSN: 18811469
• ISSN: 00218820
• HANDLE: 2115/84174
• Web Site: https://www.nature.com/articles/s41429-021-00465-8.pdf
• Web Site: https://www.nature.com/articles/s41429-021-00465-8
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN