Evaluation of nutritional availability and anti-tumor activity of selenium contained in selenium-enriched Kaiware radish sprouts
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- YOSHIDA Munehiro
- Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University High-Technology Research Center, Kansai University
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- OKADA Toshihide
- Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University
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- NAMIKAWA Yûichi
- Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University
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- MATSUZAKI Yoshimi
- Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University
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- NISHIYAMA Toshimasa
- Department of Public Health, Kansai Medical University
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- FUKUNAGA Kenji
- Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University
書誌事項
- タイトル別名
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- Evaluation of Nutritional Availability and Anti-Tumor Activity of Selenium Contained in Selenium-Enriched <I>Kaiware</I> Radish Sprouts
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We estimated the nutritional availability of selenium (Se) in Se-enriched Kaiware radish sprouts (SeRS) by the tissue Se deposition and glutathione peroxidase (GPX) activity of rats administered the sprouts, and examined the effect of SeRS on the formation of aberrant crypt foci (ACF) in the colon of mice administered 1,2-dimethylhydrazine (DMH) to evaluate anti-tumor activity. Male weanling Wistar rats were divided into seven groups and fed a Se-deficient basal diet or the basal diet supplemented with 0.05, 0.10, or 0.15 μg/g of Se as sodium selenite or SeRS for 28 d. Supplementation with Se dose-dependently increased serum and liver Se concentrations and GPX activities, and the selenite-supplemented groups showed a higher increase than the SeRS-supplemented groups. The nutritional availability of Se in SeRS was estimated to be 33 or 64% by slope ratio analysis. Male 4-week-old A/J mice were divided into seven groups and fed a low Se basal diet or the basal diet supplemented with selenite, SeRS, or selenite + non-Se-enriched radish sprouts (NonSeRS) at a level of 0.1 or 2.0 μg Se/g for 9 weeks. After 1 week of feeding, all mice were given six subcutaneous injections of DMH (20 mg/kg) at 1-week intervals. The average number of ACF formed in the colon of mice fed the basal diet was 4.3. At a supplementation level of 0.1 μg Se/g, only SeRS significantly inhibited ACF formation. At a supplementation level of 2.0 μg Se/g, both selenite and SeRS significantly inhibited ACF formation. The addition of NonSeRS to the selenite-supplemented diets tended to inhibit ACF formation, but this was not statistically significant. These results indicate that SeRS shows lower nutritional availability but higher anti-tumor activity than selenite.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 71 (9), 2198-2205, 2007
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206480020864
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- NII論文ID
- 130000022164
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8933725
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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