Clinical Efficacy of Apple Polyphenol for Treating Cedar Pollinosis
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- KISHI Kazumasa
- Otsu Nutraceutical Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- SAITO Masahiro
- Otsu Nutraceutical Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- SAITO Takao
- Otsu Nutraceutical Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- KUMEMURA Megumi
- Otsu Nutraceutical Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- OKAMATSU Hiroshi
- Otsu Nutraceutical Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- OKITA Misa
- Third Department of Internal Medicine, Tokyo Medical University
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- TAKAZAWA Kenji
- Second Department of Internal Medicine, Tokyo Medical University
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A double-blind comparative study was conducted on cedar pollinosis patients in order to evaluate the treatment efficacy of apple polyphenol (Ap). Ap was administered (500 mg) once daily for 12 weeks, starting about 2 weeks prior to cedar pollen dispersion. Pollinosis symptoms during the study were evaluated according to the classification in the guidelines for allergic rhinitis diagnosis and treatment. The results show that the sneezing score was significantly lower for the Ap group than with the placebo group during the early period of pollen dispersion and during the main dispersion period. In addition, no adverse reactions were induced by Ap during the study. These results suggest that Ap may alleviate the symptoms of cedar pollinosis.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (4), 829-832, 2005
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206475329792
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- NII論文ID
- 130000030367
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7308362
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- PubMed
- 15849424
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可