The pathophysiology of tumor necrosis factors

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  • XIE Chun
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • KOSHINO Hiroyuki
    Molecular Characterization Team, Advanced D&S Center, RIKEN
  • ESUMI Yasuaki
    Molecular Characterization Team, Advanced D&S Center, RIKEN
  • TAKAHASHI Shunya
    Molecular Characterization Team, Advanced D&S Center, RIKEN
  • YOSHIKAWA Kunie
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • ABE Naoki
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Molecular Characterization Team, Advanced D&S Center, RIKEN

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  • Vialinin A, a Novel 2,2-Diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenger from an Edible Mushroom in China

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While screening for bioactive compounds from edible mushrooms, a new potent antioxidant, vialinin A (1), together with a known compound, ganbajunin B (2), and a mixture of ganbajunins D (3) and E (4), were isolated from the dry fruiting bodies of Thelephora vialis. The structure of 1, 5′,6′-bis(phenylacetoxy)-1,1′:4′,1″-terphenyl-2′,3′,4,4″-tetraol, was elucidated by spectroscopic and chemical methods. This compound had strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging activity with an EC50 value of 14.0 μM, nearly equal to that of butylated hydroxytoluene (BHT; EC50=10.0 μM). A radical scavenging experiment using 1 and DPPH radicals indicated that 1 donated two hydrogen atoms to two molecules of the DPPH radical under hydrophobic conditions.

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