Impaired Postnatal Development in C/EBP.BETA.-deficient Mice
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- BAI Tao
- Department of Obstetrics and Gynecology, Wakayama Medical University Department of Obstetrics and Gynecology, The Second Affiliated Hospital of China Medical University
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- TANAKA Tetsuji
- Department of Obstetrics and Gynecology, Wakayama Medical University
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- YUKAWA Kazunori
- Department of Physiology, Wakayama Medical University
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- UMESAKI Naohiko
- Department of Obstetrics and Gynecology, Wakayama Medical University
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- MATSUMOTO Makoto
- Department of Host Defence, Research Institute of Microbial Disease, Osaka University
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- AKIRA Shizuo
- Department of Host Defence, Research Institute of Microbial Disease, Osaka University
Bibliographic Information
- Other Title
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- Impaired Postnatal Development in C/EBP-β-deficient Mice
- Impaired Postnatal Development in C EBP ベータ deficient Mice
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Abstract
Tail DNA genotyping of fetal and neonatal mice from C/EBPβ heterozygous parents was performed to determine whether the decreased number of surviving C/EBPβ mutants was caused by prenatal or postnatal death. Eighty-four 3-week-old mice born of heterozygous parents had significantly lower numbers of C/EBPβ-deficient offspring than the expected Mendelian ratio (29.8%+/+, 65.5%+/-, 4.76%-/-, P<0.05). The genotypes of 72 fetal mice from intercrossed heterozygotes showed approximately the expected 1:2:1 Mendelian ratio (18.1% +/+, 52.8% +/-, 29.2% -/-, P>0.05). No difference in the proportions by sex could be detected in these perinates. This data indicates that C/EBPβ-deficient mice have unknown lethal problems between the embryonic stage and weaning.<br>
Journal
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 52 (5), 645-649, 2006
The Society for Reproduction and Development
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Keywords
Details 詳細情報について
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- CRID
- 1390282681313779072
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- NII Article ID
- 130000054596
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- NII Book ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL BIB ID
- 8514064
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed