Urobilinogen, as a Bile Pigment Metabolite, Has an Antioxidant Function

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In these experiments, the antioxidative activity of urobilinogen, a major fecal pigment-related compound and reduced metabolite of bilirubin, was shown. Urobilinogen was synthesized from commercial bilirubin by reduction, and the structure was confirmed with mass spectroscopy and NMR analyses. The product was identified as <i>i</i>-urobilinogen. The DPPH radical scavenging activity of urobilinogen was higher than other antioxidants (α-tocopherol, bilirubin and β-carotene). Moreover, the formation of hydroperoxides of linoleic acid with 2, 2’-azobis (2, 4- dimethylvaleronitrile) in methanol was suppressed by the addition of synthesized urobilinogen. On the other hand, in the NMR spectrum measurement, we found the signal decrease of a proton from C<sub>10</sub> methylene. It was shown that this proton was exchanged with a deutrium of CD<sub>3</sub>OD. This methylene can easily release the hydrogen as proton donor. These results suggest that urobilinogen can inhibit the radical chain reaction by trapping free radicals.<br>

収録刊行物

  • 日本油化学会誌

    日本油化学会誌 55(4), 191-197, 2006

    公益社団法人 日本油化学会

各種コード

  • NII論文ID(NAID)
    130000055572
  • 本文言語コード
    ENG
  • ISSN
    1345-8957
  • NDL 記事登録ID
    7849783
  • NDL 雑誌分類
    ZP25(科学技術--化学・化学工業--油脂類)
  • NDL 請求記号
    Z54-J571
  • データ提供元
    NDL  J-STAGE 
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