Management of Childhood-onset Epilepsy Evaluated with a Long-term Follow-up Study

• Ohtsuka Yoko

  Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kobayashi Katsuhiro

  Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Namba Masanori

  Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Pediatrics, Faculty of Medicine, Kagawa University

• Endoh Fumika

  Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Oka Makio

  Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yoshinaga Harumi

  Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

Purpose: While many patients with childhood-onset epilepsy go into remission before reaching adulthood, a significant number of patients continue to suffer from refractory epilepsy. The purpose of this study was to clarify the long-term outcome of childhood-onset epilepsies.<BR>Subjects and Methods: We retrospectively studied 445 adult patients with childhood-onset epilepsies who were still being treated at the Department of Child Neurology, Okayama University Hospital.<BR>Results: Age at onset of epilepsy was < 7 years in 66% of the patients; 7 to 14 years in 30%; and 15 to 19 years in 5%. We classified the subjects into three groups: Group PE (289 patients) with partial epilepsy; Group GE (60 patients) with generalized epilepsy; Group RE (70 patients) consisting of patients with a history of West syndrome, Lennox-Gastaut syndrome, Doose syndrome and related epileptic syndromes; and 26 other unclassified cases. At follow-up, frequent seizures (≥ per month) were observed in 26%, 13% and 63% of patients in Groups PE, GE and RE, respectively. Of 168 patients in remission across these three groups, AEDs were discontinued or being reduced in 21% each, while 36% had experienced relapse of seizures, mainly caused by AED withdrawal.<BR>Discussion: This study indicated that these adult patients could be classified into two types: patients who still have frequent seizures even after reaching adulthood, and patients in remission or with rare seizures. For long-term management of these patients, an efficient system with cooperation between medical and comedical staff, and a comprehensive care system are essential.

収録刊行物

• Epilepsy & Seizure

  Epilepsy & Seizure 1 (1), 21-29, 2008

  一般社団法人 日本てんかん学会

キーワード

• Long-term follow-up
• Childhood-onset epilepsy
• Remission
• Relapse
• Outcome

詳細情報

• CRID: 1390001205291175680
• NII論文ID: 130000061488
• DOI: 10.3805/eands.1.21
• ISSN: 18825567
• Web Site: https://search.jamas.or.jp/link/ui/2009248346
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可