5-Azacytidine-induced Apoptosis in the Central Nervous System of Developing Rat Fetuses
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- 呂 東平 LU Dong-ping
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- 中山 裕之 NAKAYAMA Hiroyuki
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- SHINOZUKA Junko
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- UETSUKA Koji
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- TAKI Ryuichi
- Mitsubishi Kagaku Bio-Clinical Laboratories, Inc.
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- 土井 邦雄 DOI Kunio
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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Author(s)
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- 呂 東平 LU Dong-ping
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- 中山 裕之 NAKAYAMA Hiroyuki
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- SHINOZUKA Junko
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- UETSUKA Koji
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- TAKI Ryuichi
- Mitsubishi Kagaku Bio-Clinical Laboratories, Inc.
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- 土井 邦雄 DOI Kunio
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
Abstract
Pregnant Wistar rats were injected i.p. with 5-azacytidine (5AzC) at 11 day of gestation. Brain cell apoptosis determined morphologically or by TUNEL method was observed in the fetuses 3 hrs after injection. Eight to 100% of the fetuses were dead at 1 to7 day after injection. Injection with doses less than 5 mg/kg of 5AzC killed only a few fetuses, though neuronal apoptosis was detected in most of living fetuses. All fetuses were dead when their dams were injected with 5AzC at 9 or 10 day of gestation, whereas most of the fetuses were alive when injected after day 12. The present study revealed that 5AzC specifically induce neuronal apoptosis in rat fetuses at the stage of logarithmic growth.
Journal
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 11(2), 133-136, 1998-06-01
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
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YAMAUCHI Hirofumi , KATAYAMA Kei-ichi , YASOSHIMA Akira , UETSUKA Koji , NAKAYAMA Hiroyuki , DOI Kunio
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- Distribution and Sequence of Pyknotic Cells in Rat Fetuses Exposed to Busulfan
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OHIRA Toko , ANDO Ryo , ANDOH Rie , NAKAZAWA Tomomi , NISHIHARA Kaori , YAMAMOTO Satoshi , NAKAMURA Norihiko , TAMURA Kazutoshi
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- N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
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YAMAGUCHI Tsuyoshi , KANEMITSU Hiroyuki , YAMAMOTO Satoshi , KOMATSU Masahiko , UEMURA Hiroyuki , TAMURA Kazutoshi , SHIRAI Tomoyuki
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