A Phenotypic Shift from Gastric-Intestinal to Solely Intestinal Cell Types in Intestinal Metaplasia in Rat Stomach Following Treatment with X-rays.
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- Yuasa Hirofumi
- Division of Oncological Pathology, Aichi Cancer Center Research Institute Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Inada Ken-ichi
- Division of Oncological Pathology, Aichi Cancer Center Research Institute
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- Watanabe Hiromitsu
- Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
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- Tatematsu Masae
- Division of Oncological Pathology, Aichi Cancer Center Research Institute
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Histological features and genetic changes induced by X-rays in intestinal metaplasia (IM) in rats were assessed by histochemistry and immunohistochemistry. A time course study and a PCR-SSCP analysis were performed. The IMs in rats were classified into two major types according to the cells forming the metaplastic glands. The first (the GI type) had both gastric and intestinal type cells forming the metaplastic glands. The second (the I-sol type) had solely intestinal cells forming the metaplastic glands. This characterization is similar to that used to define human IMs. The occurrence of IMs of the I-sol and GI types in rats gradually increased with time after X-ray irradiation. The number of IMs of the GI type was relatively high at 2 and 4 weeks after X-ray irradiation, and was low thereafter. On the other hand, the number of IMs of the I-sol type was extremely low at 2 weeks after treatment, then increased with time, and reached a maximum at 77 weeks after treatment. In the PCR-SSCP analysis, there were no alterations of the H-ras, K-ras, and p53 genes in the IM glands of rats treated with X-ray irradiation 8 weeks earlier. These observations suggest that the phenotypic change from IMs of the GI type to the I-sol type occurred without ras and p53 gene alterations.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 15 (2), 85-93, 2002
日本毒性病理学会
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詳細情報
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- CRID
- 1390282679393016704
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- NII論文ID
- 130000065192
- 30001928572
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- NII書誌ID
- AA12022786
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- ISSN
- 1881915X
- 09149198
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可