Phenotypes of IRS-2 Deficient Mice Produced by Reproductive Technology are Stable

• HASHIMOTO Haruo

  Central Institute for Experimental Animals

• ARAI Toshiro

  Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University

• OHNISHI Yasuyuki

  Central Institute for Experimental Animals

• ETO Tomoo

  Central Institute for Experimental Animals

• ITO Mamoru

  Central Institute for Experimental Animals

• HIOKI Kyoji

  Central Institute for Experimental Animals

• SUZUKI Ryo

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• YAMAUCHI Toshimasa

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• OHSUGI Mitsuru

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• SAITO Muneo

  Central Institute for Experimental Animals

• UEYAMA Yoshito

  Department of Pathology, Tokai University School of Medicine

• TOBE Kazuyuki

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• KADOWAKI Takashi

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• TAMAOKI Norikazu

  Central Institute for Experimental Animals

• KOSAKA Kinori

  Central Institute for Experimental Animals Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

Abstract

We studied the impact of "IVF - ET" on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J- Irs2^-/- mice. The B6J-Irs2^-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of Irs2^-/- mice produced by reproductive technology are stable.<br>

Journal

• Experimental Animals

  Experimental Animals 56 (2), 149-154, 2007

  Japanese Association for Laboratory Animal Science

Keywords

• adiponectin
• embryo transfer
• IRS-2 deficient mice

Details

• CRID: 1390282680023233280
• NII Article ID: 130000068045
• NII Book ID: AA11032321
• DOI: 10.1538/expanim.56.149
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL BIB ID: 8704432
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8704432
• Web Site: http://www.jstage.jst.go.jp/article/expanim/56/2/56_2_149/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007266379
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed