High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome
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- Sakurai Kaoru
- Department of Cardiovascular Medicine, Graduate School, Tokyo Medical and Dental University
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- Wang Dongqing
- Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
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- Suzuki Jun-ichi
- Department of Cardiovascular Medicine, Graduate School, Tokyo Medical and Dental University
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- Umeda Makoto
- Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
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- Nagasawa Toshiyuki
- Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
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- Izumi Yuichi
- Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
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- Ishikawa Isao
- Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Isobe Mitsuaki
- Department of Cardiovascular Medicine, Graduate School, Tokyo Medical and Dental University
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Abstract
Recent epidemiological studies suggest that periodontitis is an important risk factor for coronary heart disease (CHD). The aim of this study was to evaluate the association between periodontitis and CHD, particularly acute coronary syndrome (ACS), focusing on microbiological and immunological features.<br> Twenty-eight CHD patients, 15 with ACS and 13 with chronic CHD, were included in this study. Coronary angiography, periodontal examination, and dental radiography were performed in all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontopathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia using polymerase chain reaction. <br> Specific serum antibody titers to the 5 periodontal pathogens were determined by enzyme-linked immunosorbent assay. It was found that 33% of the ACS patients (5/15) harbored A. actinomycetemcomitans in oral samples, whereas no A. actinomycetemcomitans (0/13) was found in the chronic CHD patients (P < 0.05). Furthermore, ACS patients showed significantly higher serum IgG titers to A. actinomycetemcomitans (P < 0.05) compared with chronic CHD. More tooth loss and alveolar bone loss were noted in ACS patients than in chronic CHD patients, although the differences were not statistically significant. <br> Periodontal pathogens, particularly A. actinomycetemcomitans, may play a role in the development of ACS. <br>
Journal
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- International Heart Journal
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International Heart Journal 48 (6), 663-675, 2007
International Heart Journal Association