Relationship between Angiotensin Converting Enzyme Gene I/D Polymorphism and Muscle Strength in Elderly

• Tobina Takuro

  Graduate School of Education, Hokkaido University

• Ayabe Makoto

  Graduate School of Education, Hokkaido University Department of Exercise Physiology, School of Health and Sports Science, Juntendo University

• Yoshitake Yutaka

  National Institute of Fitness and Sports in Kanoya

• Kimura Yasuo

  Faculty of Culture and Education, Saga University

• Miyazaki Hideo

  Graduate School of Medicine and Dental Science, Niigata University

• Ishii Kojiro

  Graduate School of Education, Hokkaido University

• Zhang Bo

  Fukuoka University School of Medicine

• Saku Keijiro

  Fukuoka University School of Medicine

• Shindo Munehiro

  Faculty of Sports and Health Science, Fukuoka University

• Kiyonaga Akira

  Faculty of Sports and Health Science, Fukuoka University

• Tanaka Hiroaki

  National Institute of Fitness and Sports in Kanoya

Abstract

Previous studies have indicated that the Angiotensin I converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism could influence human physical performance. Furthermore, a study has suggested that ACE inhibitor treatment might decrease long-term decline in muscle strength in elderly women. Thus we hypothesized that the I allele of ACE gene I/D polymorphism, which relates to lower ACE activity, might be associated with slow-decline of muscle strength in the elderly. One hundred ninety elderly people aged 72 were recruited for this study. We assessed isometric knee extension strength, leg extension power and grip strength every year for 4 years. In the preliminary measurements, physical characteristics and muscle strength were not significantly different among three genotypes. Age-related changes of the isometric knee extension, leg extension power, grip strength were similar among three genotypes. The results of this investigation suggest that ACE gene I/D polymorphism does not affect age-related change of muscle strength in the elderly.

Journal

• International Journal of Sport and Health Science

  International Journal of Sport and Health Science 4 460-464, 2006

  Japan Society of Physical Education, Health and Sport Sciences

Keywords

• Angiotensin I converting enzyme
• Polymorphism
• Aging

Details

• CRID: 1390282680262764928
• NII Article ID: 130000069806
• DOI: 10.5432/ijshs.4.460
• ISSN: 18804012
• ISSN: 13481509
• Web Site: https://search.jamas.or.jp/link/ui/2007328866
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed