Screening of periodontitis with salivary enzyme tests

• Nomura Yoshiaki

  Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine Department of Oral Health, National Institute of Public Health

• Tamaki Yoh

  Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine Department of Oral Health, National Institute of Public Health Division of Oral Health, Department of Health Science, Kanagawa Dental College

• Tanaka Tomoko

  Department of Oral Health, Nippon Dental University School of Life Dentistry at Tokyo

• Arakawa Hirohisa

  Division of Oral Health, Department of Health Science, Kanagawa Dental College

• Tsurumoto Akihisa

  Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine

• Kirimura Kazuko

  Research Center for Odontology, Nippon Dental University School of Life Dentistry at Tokyo

• Sato Tsutomu

  Department of Oral Health, Nippon Dental University School of Life Dentistry at Tokyo

• Hanada Nobuhiro

  Department of Oral Health, National Institute of Public Health

• Kamoi Kyuichi

  Department of Oral Health, National Institute of Public Health Nippon Dental University School of Life Dentistry at Tokyo

抄録

The purpose of this study was to determine the usefulness of salivary biochemical markers for the screening of periodontal disease and examine the agreement between the results of saliva enzyme tests and those of probing depth. The present study included a total of 187 subjects who underwent annual medical check-ups at the Comprehensive Health Care Center, Honjo, Saitama Prefecture, Japan. Periodontal pocket probing was performed with a WHO probe, and various enzymes and biochemical parameters in saliva were measured. For lactate dehydrogenase (LDH), the proportions of the five isoenzymes were calculated. To decide the cut-off point for each enzymatic activity, receiver operating characteristic curves (ROC curves) were constructed and the points of minimum difference between sensitivity and specificity were decided. Among the biochemical markers tested, salivary LDH level had the highest sensitivity and specificity (sensitivity 0.66, specificity 0.67), while salivary levels of aspartate aminotransferase (AST) and blood urea nitrogen (BUN) also had sensitivity and specificity above 0.60. Among the LDH isoenzymes, LDH4 and LDH5 dominated in whole saliva samples. Salivary LDH may be a feasible and useful parameter for the screening of periodontal disease, while salivary AST and BUN also appear to be potentially useful for this purpose. (J. Oral Sci. 48, 177-183, 2006)

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒａｌ　Ｓｃｉｅｎｃｅ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒａｌ　Ｓｃｉｅｎｃｅ 48 (4), 177-183, 2006

  日本大学歯学部

キーワード

• periodontal disease
• periodontal pocket probing
• community periodontal index
• lactate dehydrogenase
• saliva

詳細情報

• CRID: 1390282680022310528
• NII論文ID: 130000072707
• DOI: 10.2334/josnusd.48.177
• ISSN: 18804926
• ISSN: 13434934
• Web Site: https://www.jstage.jst.go.jp/article/josnusd/48/4/48_4_177/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007217093
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可