Topical capsaicin application causes cold hypersensitivity in awake monkeys

DOI Web Site 9 References
  • Kamo Hiroshi
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Honda Kuniya
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Kitagawa Junichi
    Department of Physiology, Nihon University School of Dentistry Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry
  • Tsuboi Yoshiyuki
    Department of Physiology, Nihon University School of Dentistry Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry
  • Kondo Masahiro
    Department of Physiology, Nihon University School of Dentistry Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry
  • Taira Masato
    Advanced Research Institute for the Sciences and Humanities Life Science, Nihon University Advanced Research Institute for the Sciences and Humanities
  • Yamashita Akiko
    Division of Applied System Neuroscience Advanced Medical Research Center, Nihon University Graduate School of Medical Science
  • Katsuyama Narumi
    Division of Applied System Neuroscience Advanced Medical Research Center, Nihon University Graduate School of Medical Science
  • Masuda Yuji
    Institute for Oral Science, Division of Oral and Maxillofacial Biology, Matsumoto Dental University
  • Kato Takafumi
    Institute for Oral Science, Division of Oral and Maxillofacial Biology, Matsumoto Dental University
  • Iwata Koichi
    Department of Physiology, Nihon University School of Dentistry Division of Applied System Neuroscience Advanced Medical Research Center, Nihon University Graduate School of Medical Science Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry

Search this article

Abstract

Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in cold stimulus temperature (30°C to 0.5, 1.0, 1.5 or 2.0°C) applied to the facial skin. A total of 589 trials were studied, and the number of escape and hold-through trials and detection latency were measured. The number of escape trials was increased after capsaicin treatment, whereas that of hold-through trials was decreased. Detection latency was significantly decreased after capsaicin treatment. The present findings suggest that topical application of capsaicin to the facial skin induces reversible hypersensitivity to a facial cold stimulus in behaving monkeys. (J. Oral Sci. 50, 175-179, 2008)

Journal

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top