Formaldehyde-Induced Shrinkage of Rat Thymocytes

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著者

    • NISHIZAKI Yasutaka
    • Laboratory of Cell Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • NODA Katuhiko
    • Laboratory of Cell Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima
    • OKANO Yoshiro
    • Department of Pharmaceutical Care and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • OYAMA Yasuo
    • Laboratory of Cell Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima

抄録

To test the possibility that micromolar formaldehyde, a metabolite of methanol derived from aspartame, exerts cytotoxicity, its effect on rat thymocytes was examined under the in vitro condition using a flow cytometer. Incubation of thymocytes with formaldehyde at 100 μM or more for 24 h significantly increased the populations of shrunken cells and cells with hypodiploid DNA. The peak blood concentration of methanol in human subjects administered abuse doses of aspartame has been reported to exceed 2 mg/dL (625 μM). It would increase the population of thymocytes undergoing apoptosis if formaldehyde at 100 μM or more appears in the blood after administration of aspartame.<br>

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 91(1), 83-86, 2003-01-01

    公益社団法人 日本薬理学会

参考文献:  13件中 1-13件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    130000073733
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    6494569
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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