ATP- and Adenosine-Mediated Signaling in the Central Nervous System: The Role of Extracellular ATP in Hippocampal Long-Term Potentiation
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- Fujii Satoshi
- Department of Physiology, Yamagata University School of Medicine
Bibliographic Information
- Other Title
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- The Role of Extracellular ATP in Hippocampal Long-Term Potentiation
- Role of Extracellular ATP in Hippocampal Long Term Potentiation
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Abstract
Application of 10 μM ATP for 10 min transiently depressed, then slowly augmented, synaptic transmission in CA1 neurons, leading to long-term potentiation (LTP) (ATP-induced LTP). This ATP-induced LTP was blocked by addition of an N-methyl-<sc>D</sc>-aspartate (NMDA) glutamate receptor antagonist, <sc>D</sc>,<sc>L</sc>-2-amino-5-phosphonovalerate (5 μM). For ATP-induced LTP, delivery of test synaptic inputs once every 20 s to CA1 neurons could be substituted by application of 100 nM NMDA during ATP perfusion. In addition, ATP-induced LTP was blocked by co-application of an ecto-protein kinase inhibitor, K-252b (40 nM), whereas a P2X purinoceptor antagonist, pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid 4-sodium (50 μM), or a P2Y purinoceptor antagonist, basilen blue (10 μM), had no effect. These results, therefore, indicate that the mechanisms of ATP-induced LTP involve the modulation of NMDA receptors / Ca2+ channels and the phosphorylation of extracellular domains of synaptic membrane proteins, one of which could be the NMDA receptor / Ca2+ channel.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 94 (2), 103-106, 2004
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282680154421120
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- NII Article ID
- 130000073859
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 6863500
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- PubMed
- 14978345
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed