Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia

• Kitamura Yoshihisa

  Department of Neurobiology, Kyoto Pharmaceutical University

• Takata Kazuyuki

  Department of Neurobiology, Kyoto Pharmaceutical University

• Inden Masatoshi

  Department of Neurobiology, Kyoto Pharmaceutical University

• Tsuchiya Daiju

  Department of Neurobiology, Kyoto Pharmaceutical University

• Yanagisawa Daijiro

  Department of Neurobiology, Kyoto Pharmaceutical University

• Nakata Junko

  Department of Neurobiology, Kyoto Pharmaceutical University

• Taniguchi Takashi

  Department of Neurobiology, Kyoto Pharmaceutical University

抄録

Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 94 (2), 203-206, 2004

  公益社団法人 日本薬理学会

キーワード

• microglia
• neuroprotection
• focal brain ischemia

詳細情報

• CRID: 1390282680154387840
• NII論文ID: 130000073874
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.94.203
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 6863777
• PubMed: 14978360
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6863777
• Web Site: https://search.jamas.or.jp/link/ui/2004183478
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可