Characterization of GABAB Receptor in the Human Colon

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  • Uezono Yasuhito
    Division of Pharmacology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Kaibara Muneshige
    Division of Pharmacology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Hayashi Hideki
    Division of Pharmacology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Kawakami Shunsuke
    Division of Surgery, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Enjoji Akihito
    Division of Surgery, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Kanematsu Takashi
    Division of Surgery, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Taniyama Kohtaro
    Division of Pharmacology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences

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Abstract

Characterization of the GABAB receptor in the human colon was performed by the reverse transcription-polymerase chain reaction (RT-PCR). mRNAs for both subunits of the GABAB receptor, GABAB1 and GABAB2, were detected in the human colon. The GABAB1(e) isoform was detected in the human colon, but not in the brain, and the other isoforms, except GABAB1(d), were detected in both tissues. Thus, the GABAB receptor may be present as a heterodimer with subunits of GABAB1 and GABAB2 in the human colon.<br>

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