Decreased Levels of Circulating .ALPHA.2-Heremans-Schmid Glycoprotein/Fetuin-A (AHSG) in Patients with Rheumatoid Arthritis

• Sato Hiroe

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Kazama Junichiro J

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Wada Yoko

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Kuroda Takeshi

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Narita Ichiei

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Gejyo Fumitake

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Gao Ping

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

• Yamashita Hiroyuki

  Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences

抄録

Objective Alpha2-Heremans Schmid glycoprotein/Fetuin-A (AHSG) is a circulating negative acute-phase protein, which inhibits bimineralization. It is often considered as a potential mediator between chronic inflammation and cardiovascular diseases. The metabolism of AHSG in patients with rheumatoid arthritis (RA) is unknown.<br> Methods Serum AHSG concentrations were measured in 102 patients with RA using a newly developed indirect enzyme-linked immunosorbent assay (ELISA).<br> Results The serum AHSG levels in the RA patients were significantly lower than that in healthy volunteers (249.8 ± 84.1 vs 425.0 ± 93.0 μg/ml, P<0.0001). Serum C-reactive protein concentration and erythrocyte sedimentation rate were inversely correlated, while albumin, hemoglobin and total cholesterol were positively correlated with AHSG. Current serum AHSG levels did not affect the presence of aortic calcification, whereas cumulative glucocorticoid dosage was significantly related to aortic calcification (P=0.005).<br> Conclusion Serum AHSG levels were significantly decreased in patients with RA. The levels reflected inflammatory and malnutritional conditions. Its role in the development of cardiovascular diseases or inflammatory bone resorption remain uncertain in RA patients.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 46 (20), 1685-1692, 2007

  一般社団法人 日本内科学会

キーワード

• α2-Heremans-Schmid Glycoprotein/Fetuin-A (AHSG)
• reumatoid arthritis
• vascular calcification

詳細情報

• CRID: 1390001204870256640
• NII論文ID: 130000075946
• DOI: 10.2169/internalmedicine.46.6269
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/46/20/46_20_1685/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008171447
• 本文言語コード: en
• データソース種別:
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  • CiNii Articles
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