Disease Severity in Patients with Simultaneous Influenza and Bacterial Pneumonia

• Seki Masafumi

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences Second Department of Internal Medicine, Nagasaki University School of Medicine Kitakyushu City Yahata Hospital

• Kosai Kosuke

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences Second Department of Internal Medicine, Nagasaki University School of Medicine Kitakyushu City Yahata Hospital

• Yanagihara Katsunori

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Higashiyama Yasuhito

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences

• Kurihara Shintaro

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Izumikawa Koichi

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences Second Department of Internal Medicine, Nagasaki University School of Medicine

• Miyazaki Yoshitsugu

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences Second Department of Internal Medicine, Nagasaki University School of Medicine

• Hirakata Yoichi

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences Second Department of Internal Medicine, Nagasaki University School of Medicine

• Tashiro Takayoshi

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Kohno Shigeru

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences

Abstract

Objective To determine the differences in the clinical features of bacterial pneumonia patients between patients co-infected with influenza virus or not co-infected.<br> Methods Fifteen adult patients with bacterial pneumonia (7 men and 8 women) who also tested positive for influenza virus antigen were compared with those with bacterial pneumonia alone (n=28).<br> Results Complications with chronic lung diseases were more frequently found in bacterial pneumonia patients with influenza virus infection, compared with those who had bacteria pneumonia alone. Statistical differences were also found in body temperature, and heart rates between the two groups. CRP levels, chest X-ray infiltrates and the severity of pneumonia, as determined using the criteria of the Japan Respiratory Society (JRS) and/or the Infectious Diseases Society of America (IDSA), were also significantly worse in patients of bacterial pneumonia infected with influenza virus, than in those who had bacterial pneumonia alone.<br> Conclusions The severity of pneumonia in patients co-infected with influenza virus and bacteria was significantly higher than in those infected with bacteria alone. These data suggested that the influenza virus infection enhanced the bacterial pneumonia. Further study of the pathogenesis of the synergic interaction between influenza virus and bacteria is warranted. <br>

Journal

• Internal Medicine

  Internal Medicine 46 (13), 953-958, 2007

  The Japanese Society of Internal Medicine

Keywords

• influenza virus
• bacterial pneumonia
• co-infection

Details

• CRID: 1390001204872552192
• NII Article ID: 130000076148
• DOI: 10.2169/internalmedicine.46.6364
• COI: 1:STN:280:DC%2BD2szos1emtw%3D%3D
• ISSN: 13497235
• ISSN: 09182918
• HANDLE: 10069/22572
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/16689
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/46/13/46_13_953/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008064241
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed