Development of Hepatocellular Carcinoma in a Woman with HBV- and HCV-negative Autoimmune Hepatitis with Unsatisfactory Response to Corticosteroid

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Author(s)

    • NAKAMURA Shinichiro
    • Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama
    • KOBAYASHI Yoshiyuki
    • Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama
    • FUJIOKA Shin-ichi
    • Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama
    • IWASAKI Yoshiaki
    • Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama
    • SHIRATORI Yasushi
    • Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama

Abstract

A 57-year-old woman was admitted due to a hemorrhage from esophageal varices. Laboratory tests showed liver dysfunction, elevated immunoglobulin G levels and positivity for anti-nuclear antibodies. Serum hepatitis B virus and hepatitis C virus markers were negative. The liver biopsy specimen was compatible with autoimmune hepatitis, and low-dose prednisolone was started. During the follow-up, her serum alanine aminotransferase levels continued to fluctuate between 40 and 60 IU/<i>l</i>. Nine years later, hepatocellular carcinoma 20 mm in diameter was detected. This case suggests that hepatocellular carcinoma develops even if serum alanine aminotransferase levels are maintained at less than twice the upper normal limit.

Journal

  • Internal Medicine

    Internal Medicine 44(9), 949-953, 2005

    The Japanese Society of Internal Medicine

Cited by:  2

Codes

  • NII Article ID (NAID)
    130000076311
  • NII NACSIS-CAT ID (NCID)
    AA10827774
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0918-2918
  • NDL Article ID
    7430494
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z53-M398
  • Data Source
    CJPref  NDL  J-STAGE 
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