Microscopic Polyangiitis after Influenza Vaccination

  • UJI Masato
    Department of Internal Medicine, Osaka Prefectural Rehabilitation Center For Physically Disabled Persons
  • MATSUSHITA Haruhiko
    Department of Respirology, Izumi City Hospital
  • IWATA Shinichi
    Department of Cardiology, Graduate School of Medicine, Osaka City University

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After influenza vaccination an 83-year-old woman was referred to us because of fever and sore throat with no response to antibiotics. Chest computed tomography showed thickened bronchovascular bundles, multiple nodules with feeding vessels, and consolidation. Laboratory tests showed a high level of serum myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) and soluble interleukin-2 receptor (sIL-2R), as well as abnormal renal function and urinary sediment. Transbronchial lung biopsy revealed organizing pneumonia. We made a diagnosis of microscopic polyangiitis after influenza vaccination. Corticosteroids and cyclophosphamide were effective. Careful attention should be paid to severe adverse effects such as systemic vasculitides after influenza vaccination.

収録刊行物

  • Internal Medicine

    Internal Medicine 44 (8), 892-896, 2005

    一般社団法人 日本内科学会

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