CD8-positive T Cell-induced Liver Damage was Found in a Patient with Polymyositis

• Takahashi Atsushi

  Divisions of Rheumatology, Ohta Nishinouchi Hospital

• Takeda Isao

  Divisions of Rheumatology, Ohta Nishinouchi Hospital

• Kanno Takashi

  Divisions of Rheumatology, Ohta Nishinouchi Hospital

• Nakahara Toshiki

  Divisions of Neurology, Ohta Nishinouchi Hospital

• Odajima Hajime

  Divisions of Pathology, Ohta Nishinouchi Hospital

• Kasukawa Reiji

  Divisions of Rheumatology, Ohta Nishinouchi Hospital

抄録

We describe a case of polymyositis (PM) with liver injury that occurred in a patient with rheumatoid arthritis (RA). A 74-year-old woman who had a 12-year history of RA was admitted to our hospital because of muscle weakness and liver dysfunction. CD8-positive T cell infiltration was found in the interstitium of both the liver and muscle. In addition to the administration of a large amount of prednisolone (PSL), high-dose intravenous immunoglobulin (IVIG) successfully improved myositis and hepatitis. Our case indicates the pathogenic potential of CD8-positive T cells in PM-associated liver injury.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 45 (18), 1059-1063, 2006

  一般社団法人 日本内科学会

キーワード

• polymyositis
• liver disturbance
• CD8-positive T cell
• IVIG

詳細情報

• CRID: 1390001204872947072
• NII論文ID: 130000076441
• DOI: 10.2169/internalmedicine.45.1710
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/45/18/45_18_1059/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007232731
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可