Clinical Outcome of Patients with SREDA (Subclinical Rhythmic EEG Discharge of Adults)

  • Begum Tahamina
    Human Brain Research Center, Kyoto University Graduate School of Medicine
  • Ikeda Akio
    Departments of Neurology, Kyoto University Graduate School of Medicine
  • Takahashi Jun
    Departments of Neurosurgery, Kyoto University Graduate School of Medicine
  • Tomimoto Hidekazu
    Departments of Neurology, Kyoto University Graduate School of Medicine
  • Shimohama Shun
    Departments of Neurology, Kyoto University Graduate School of Medicine
  • Satow Takeshi
    Human Brain Research Center, Kyoto University Graduate School of Medicine
  • Nagamine Takashi
    Human Brain Research Center, Kyoto University Graduate School of Medicine
  • Fukuyama Hidenao
    Human Brain Research Center, Kyoto University Graduate School of Medicine
  • Shibasaki Hiroshi
    Human Brain Research Center, Kyoto University Graduate School of Medicine Departments of Neurology, Kyoto University Graduate School of Medicine Takeda General Hospital

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Objective: To clarify the clinical significance of subclinical rhythmic EEG discharge of adults' (SREDA) by analyzing characteristics of SREDA and the outcome of patients based on retrospective analysis of EEG data base.<br> Methods: EEGs were recorded soon after the onset of patient's initial symptoms and repeatedly recorded at various intervals of 23 months in all 4 patients. Neurological findings, MRI and SPECT were also investigated.<br> Subjects: Out of 340 consecutive inpatient population who had EEGs, 4 patients (1.2%) showed SREDA. They had a diagnosis of syncope, transient global amnesia, generalized tonicclonic seizure and right temporal lobe epilepsy for each.<br> Results: There was no consistent abnormality in the brain MRI, CT or SPECT among the 4 patients. The acute and transient symptoms disappeared and did not recur within the followup period of 28 months in any patient. In 2 patients SREDA disappeared in the followup EEG taken 714 days after the first EEG showing SREDA. In the other 2 patients, the followup EEGs taken 5 days after the first EEG with SREDA when clinical symptoms disappeared showed less frequent occurrence of SREDA.<br> Conclusion: Being different from the previous reports suggesting the relation with cardiogenic insults or persistent ischemic abnormality, SREDA can occur in patients with various acute brain dysfunctions followed by a favorable clinical outcome.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 45 (3), 141-144, 2006

    一般社団法人 日本内科学会

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