Acute Disseminated Encephalomyelitis Associated with Oral Polio Vaccine

  • Shibazaki Kensaku
    Division of Neurology, Department of Internal Medicine, Kawasaki Medical School
  • Murakami Tatsufumi
    Division of Neurology, Department of Internal Medicine, Kawasaki Medical School
  • Kushida Ryutaro
    Division of Neurology, Department of Internal Medicine, Kawasaki Medical School
  • Kurokawa Katsumi
    Division of Neurology, Department of Internal Medicine, Kawasaki Medical School
  • Terada Kihei
    Division of Neurology, Department of Pediatrics, Kawasaki Medical School
  • Sunada Yoshihide
    Division of Neurology, Department of Internal Medicine, Kawasaki Medical School

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Abstract: A 27-year-old woman presented with acute paresis after taking an oral polio vaccine (OPV). Deep tendon reflexes were preserved, needle electromyography showed no neurogenic changes, and there were no lesions on spine magnetic resonance imaging (MRI), suggesting that motor neurons of the spinal cord were not affected. Brain MRI showed abnormal lesions in the tegmentum of the upper pons, left cerebral peduncles, truncus of the corpus callosum, and right parietal lobe. Cerebrospinal fluid revealed mild pleocytosis. The most probable diagnosis was acute disseminated encephalomyelitis associated with OPV.<br>

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  • Internal Medicine

    Internal Medicine 45 (20), 1143-1146, 2006

    一般社団法人 日本内科学会

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