Mechanism of Constipation in Familial Amyloid Polyneuropathy: a Case Report

• Ito Takashi

  Department of Neurology, Chiba University

• Sakakibara Ryuji

  Department of Neurology, Chiba University

• Ito Shoichi

  Department of Neurology, Chiba University

• Uchiyama Tomoyuki

  Department of Neurology, Chiba University

• Liu Zhi

  Department of Neurology, Chiba University

• Yamamoto Tatsuya

  Department of Neurology, Chiba University

• Yamaguchi Taketo

  Department of Gastroenterology, Chiba University

• Odaka Takeo

  Department of Gastroenterology, Chiba University

• Higashi Morihiro

  Department of Molecular and Tumor Pathology, Chiba University

• Hattori Takamichi

  Department of Neurology, Chiba University

抄録

Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a prolonged colonic transit time, a low anal pressure at rest and upon squeezing, loss of the spontaneous phasic rectal contractions, and weak abdominal strain. All these abnormalities suggested a peripheral autonomic dysfunction, corresponding to the enteric neuropathy that was confirmed upon autopsy.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 45 (20), 1173-1175, 2006

  一般社団法人 日本内科学会

キーワード

• familial amyloid polyneuropathy
• transthyretin
• functional gut dysfunction
• enteric neuropathy
• autonomic dysfunction

詳細情報

• CRID: 1390282679846895616
• NII論文ID: 130000076636
• DOI: 10.2169/internalmedicine.45.1570
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/45/20/45_20_1173/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007249910
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可