Repeated Adenosine Pre-treatment Potentiates the Acute Effect of Methamphetamine in Rats.

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  • Kawashimo Atsuko
    Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Kyushu University 62,Fukuoka 812-8582,Japan
  • Shimazoe Takao
    Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Kyushu University 62,Fukuoka 812-8582,Japan
  • Yoshimatsu Akiko
    Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Kyushu University 62,Fukuoka 812-8582,Japan
  • Watanabe Shigenori
    Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Kyushu University 62,Fukuoka 812-8582,Japan

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抄録

Adenosine was intraperitoneally(i.p.)injected to Wistar rats every 3 days with a total of 5 administrations.After a 7−day withdrawal, the animals were challengedwith methamphetamine(0.5 mg/kg, i.p.).The effect of methamphetamine on locomotor activity was significantly potentiated by repeated adenosine pre−treatment.Moreover, methamphetamine−induced dopamine release was also increased in the striatum.Methamphetamine−induced hyperactivity and dopamine release were significantly potentiated by repeated pre−treatment of an adenosine A1 agonist, N6−cyclohexyladenosine(0.5 mg/kg, i.p.).These results suggest that the acute effect of methamphetamine is potentiated by repeated pre−treatment of adenosine via adenosine A1 receptors.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 84 (1), 78-81, 2000

    公益社団法人 日本薬理学会

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