Hyperglycemia Promotes Microinflammation as Evaluated by C-Reactive Protein in the Very Elderly

Access this Article

Search this Article

Author(s)

    • Fukuhara Masayo
    • Division of General Internal Medicine, Kyushu Dental College, Kitakyushu|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Iida Mitsuo
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Matsumura Kiyoshi
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Takata Yutaka
    • Division of General Internal Medicine, Kyushu Dental College, Kitakyushu
    • Sonoki Kazuo
    • Division of General Internal Medicine, Kyushu Dental College, Kitakyushu
    • Fujisawa Kiyoshi
    • Division of General Internal Medicine, Kyushu Dental College, Kitakyushu
    • Akifusa Sumio
    • Division of Community Oral Health Science, Kyushu Dental College
    • Fujii Koji
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

Abstract

<b>Objective:</b> C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of subclinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly.<br> <b>Methods:</b> The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) levels were used as an index of glycemic control.<br> <b>Results:</b> The HbA<sub>1c</sub> level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The HbA<sub>1c</sub> was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01±0.29%, 5.57±0.09% and 5.42±0.05%, respectively). Furthermore, the HbA<sub>1c</sub> adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA<sub>1c</sub> level was significantly and independently associated with the CRP level.<br> <b>Conclusions:</b> These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.<br>

Journal

  • Internal Medicine

    Internal Medicine 46(5), 207-212, 2007

    The Japanese Society of Internal Medicine

Codes

Page Top