Hyperglycemia Promotes Microinflammation as Evaluated by C-Reactive Protein in the Very Elderly

• Fukuhara Masayo

  Division of General Internal Medicine, Kyushu Dental College, Kitakyushu Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Matsumura Kiyoshi

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Wakisaka Masanori

  Division of General Internal Medicine, Kyushu Dental College, Kitakyushu

• Takata Yutaka

  Division of General Internal Medicine, Kyushu Dental College, Kitakyushu

• Sonoki Kazuo

  Division of General Internal Medicine, Kyushu Dental College, Kitakyushu

• Fujisawa Kiyoshi

  Division of General Internal Medicine, Kyushu Dental College, Kitakyushu

• Ansai Toshihiro

  Division of Community Oral Health Science, Kyushu Dental College

• Akifusa Sumio

  Division of Community Oral Health Science, Kyushu Dental College

• Fujii Koji

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Iida Mitsuo

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Takehara Tadamichi

  Division of Community Oral Health Science, Kyushu Dental College

Abstract

Objective: C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of subclinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly.<br> Methods: The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A_1c (HbA_1c) levels were used as an index of glycemic control.<br> Results: The HbA_1c level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The HbA_1c was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01±0.29%, 5.57±0.09% and 5.42±0.05%, respectively). Furthermore, the HbA_1c adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA_1c level was significantly and independently associated with the CRP level.<br> Conclusions: These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.<br>

Journal

• Internal Medicine

  Internal Medicine 46 (5), 207-212, 2007

  The Japanese Society of Internal Medicine

Keywords

• atherosclerosis
• HbA_1c
• C-reactive protein
• elderly

Details

• CRID: 1390282679847781120
• NII Article ID: 130000078552
• DOI: 10.2169/internalmedicine.46.1868
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/46/5/46_5_207/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007250136
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed