Fatal Cytomegalovirus-Associated Adrenal Insufficiency in an AIDS Patient Receiving Corticosteroid Therapy
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- Uno Kenji
- Center for Infectious Diseases, Nara Medical University
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- Konishi Mitsuru
- Center for Infectious Diseases, Nara Medical University
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- Yoshimoto Eiichiro
- Center for Infectious Diseases, Nara Medical University
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- Kasahara Kei
- Center for Infectious Diseases, Nara Medical University
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- Mori Kei
- Center for Infectious Diseases, Nara Medical University
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- Maeda Koichi
- Department of General Medicine, Nara Medical University
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- Ishida Eiwa
- Department of Pathology, Nara Medical University
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- Konishi Noboru
- Department of Pathology, Nara Medical University
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- Murakawa Koichi
- Sekiya Hospital
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- Mikasa Keiichi
- Center for Infectious Diseases, Nara Medical University
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A 35-year-old homosexual man, who had already received sulfamethoxazole/trimethoprim and steroid therapy because of human immunodeficiency virus (HIV)-related Pneumocystis jiroveci pneumonia, was referred to our hospital. He was also diagnosed as having cytomegalovirus (CMV) co-infection, and started receiving intravenous gancyclovir for CMV infection on the 2nd day of admission into our hospital. He had to continue the steroid therapy because his respiratory condition did not improve. On the 10th hospitalization day, when 40 mg of prednisolone was administered, cardiopulmonary arrest suddenly occurred, and his laboratory data showed hyponatremia and hyperpotassemia. In spite of resuscitation, he died two days later. The postmortem examination revealed that he died of adrenal failure due to CMV infection. In general, CMV is thought to cause adrenalitis, but rarely leads to manifestations of adrenal insufficiency during the clinical course. It is important to be aware that grave adrenal failure due to CMV infection can develop even under steroid therapy.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 46 (9), 617-620, 2007
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679847656448
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- NII論文ID
- 130000078725
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- ISSN
- 13497235
- 09182918
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 使用不可