Cigarette Smoking and Mortality in Japan: The Miyagi Cohort Study

  • Hozawa Atsushi
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Ohkubo Takayoshi
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Yamaguchi Junko
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Ugajin Takashi
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Koizumi Yayoi
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Nishino Yoshikazu
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Tsubono Yoshitaka
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Shibuya Daisuke
    Miyagi Cancer Society
  • Tsuji Ichiro
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • Fukao Akira
    Department of Public Health, Yamagata University School of Medicine
  • Hisamichi Shigeru
    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine

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BACKGROUND: We examined the association between smoking and all-cause mortality among Japanese men and women.<br>METHODS: In 1990, 18,945 men and 17,107 women in Miyagi Prefecture in rural northern Japan (40-64 year of age) completed a self-administered questionnaire including items on smoking. Cox regression was used to estimate relative risk (RR) of mortality according to smoking categories, with adjustment for age, education, marital status, past history of diseases, drinking, body mass index, walking, and dietary variables. During 11 years of follow-up, 1,209 men and 499 women had died.<br>RESULTS: Multivariate RRs of all-cause mortality for current smokers as compared with never smokers were 1.71 (95% confidence interval, 1.44-2.03) for men and 1.44 (95% confidence interval, 1.06-1.94) for women. Among men, risk in past smokers who had quit smoking for 15 years or longer was not different from the risk in never smokers (RR, 0.97; 95% confidence interval, 0.68-1.39). Of all deaths, 34% in men and 4% in women were attributable to current or past smoking.<br>CONCLUSIONS: This study indicates that smoking increases the risk of premature death among middle-aged Japanese men and women and that substantial proportion of death, especially for men, is attributable to smoking.

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