アレルギーとフラボノイド  [in Japanese] Allergy and Flavonoid  [in Japanese]

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Author(s)

    • 田中 敏郎 TANAKA Toshio
    • 大阪大学大学院医学系研究科呼吸器・免疫アレルギー・感染内科学講座 Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School
    • 平野 亨 HIRANO Toru
    • 大阪大学大学院医学系研究科呼吸器・免疫アレルギー・感染内科学講座 Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School
    • 比嘉 慎二 [他] HIGA Shinji
    • 大阪大学大学院医学系研究科呼吸器・免疫アレルギー・感染内科学講座 Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School
    • 有光 潤介 ARIMITSU Junsuke
    • 大阪大学大学院医学系研究科呼吸器・免疫アレルギー・感染内科学講座 Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School
    • 河合 麻理 KAWAI Mari
    • 大阪大学大学院医学系研究科呼吸器・免疫アレルギー・感染内科学講座 Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School

Abstract

この数十年間でアレルギー疾患の有病率が増加しているが,種々の環境変化の中で食習慣の変化も有病率の増加に関与しているものと推測されている.果物,野菜やお茶に含まれるフラボノイドは,好塩基球や肥満細胞からのヒスタミンや IL-4, IL-13 などのサイトカインまた CD40 リガンドの発現を抑制する活性を有する.ルテオリン,アピゲニンとフィセチンに強い活性 (IC50=2–5 μM) が認められ,また日常摂取の多いケルセチン,ケンフェロールにも中等度の抑制活性 (IC50=15–18 μM) が観察された.その作用機序として,転写因子 NFAT と AP-1 の活性化を抑制することが示された.フラボノイドをアトピー性皮膚炎のモデルマウスに投与することで,発症や症状軽減が認められる.また,疫学研究において,フラボノイドの高摂取群では喘息の発症率が低かった報告もなされており,適切なフラボノイドの摂取がアレルギー疾患に対する予防や補完代替医療となる可能性が期待される.<br>

The prevalence of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis has increased all over the world during the last two decades. Dietary change is supposed to be associated with this increase. If it is the case, an appropriate intake of foods or drinks with anti-allergic functions is expected to stop the increase. Flavonoids, ubiquitously present in vegetables, fruits or teas possess anti-allergic activities. Flavonoids inhibit histamine release, synthesis of IL-4 and IL-13 and CD40 ligand expression by basophils and mast cells. Analyses of structure-activity relationships of representative flavones showed that luteolin, apigenin and fisetin were the strongest inhibitors of IL-4 production with an IC<sub>50</sub> value of 2–5 μM and determined a fundamental structure for the inhibitory activity. Quercetin and kaempferol showed a substantial activity with an IC<sub>50</sub> value of 15–18 μM. The inhibitory activity of flavonoids on IL-4 and CD40 ligand expression were thought to be mediated through their inhibitory action on activation of nuclear factor of activated T cells and AP-1. Administration of flavonoids into atopic dermatitis-prone mice prevented the onset of dermatitis and serum IgE elevation and ameliorated the severity of dermatitis even after the onset. In addition a preliminary trial of flavonoids for adult patients with atopic dermatitis showed a significant effect. Recent epidemiological studies reported that a low incidence of asthma was significantly observed by population with a high intake of flavonoids. Thus, these evidences will be helpful for the development of low molecular compounds for allergic diseases and it is expected that an appropriate daily intake of flavonoids may be an effective complementary and alternative medicine and a preventative strategy for allergic diseases.<br>

Journal

  • Japanese Journal of Complementary and Alternative Medicine

    Japanese Journal of Complementary and Alternative Medicine 3(1), 1-8, 2006

    The Japanese Society for Complementary and Alternative Medicine

Codes

  • NII Article ID (NAID)
    130000079399
  • NII NACSIS-CAT ID (NCID)
    AA12095429
  • Text Lang
    JPN
  • ISSN
    1348-7922
  • NDL Article ID
    7863156
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z74-E199
  • Data Source
    NDL  J-STAGE 
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