運動と免疫  [in Japanese] Exercise and Immunity  [in Japanese]

Access this Article

Author(s)

    • 鈴木 克彦 SUZUKI Katsuhiko
    • 早稲田大学人間科学部健康福祉科学科 Department of Health Science and Social Welfare, School of Human Sciences, Waseda University

Abstract

適度な運動は免疫能を高め,感染症や癌の予防に有効とされる一方,激しい運動やトレーニングは免疫能を弱め,炎症やアレルギーを助長するとされる.これらの機序については,激しい運動やトレーニングに伴い血中 NK 細胞・ T 細胞の数や機能,分泌型 IgA の唾液濃度などが一過性に低下し,免疫抑制作用のあるストレスホルモンや抗炎症性サイトカインが分泌され,易感染性につながると考えられている.一方,激運動に伴い好中球・単球が動員され活性酸素の産生が高まり,炎症反応や酸化ストレスを引き起こすが,適切な栄養・休養に加え,抗酸化物質等のサプリメントの使用によりこれらの反応を制御できる可能性が示されつつある.また,適度な運動習慣がストレスや感染に対する抵抗力(防衛体力)を強化するという科学的根拠が集積されつつある.本稿では予防医学・補完代替医療の適用の是非を念頭に置いて,運動免疫学分野の最新の研究成果を紹介する.<br>

It is generally accepted that moderate physical activity can improve immune functions and potentially reduce the risk of developing infectious diseases and cancer. There is accumulating evidence to show that moderate physical activity can enhance the activities of T cells, natural killer cells and macrophages, cytokine productivity and serum immunoglobulin (Ig) G and salivary IgA levels. In contrast, however, exhaustive exercise causes the systemic release of immunosuppressive stress hormones and anti-inflammatory cytokines, and temporarily causes a decrease in circulating lymphocyte counts and the reduction in activities of T cells and natural killer cells and salivary IgA levels. Consequently, these negative alterations in immune function and cytokine imbalance may enhance host susceptibility to infections and promote allergic disposition. Although exercise-induced mobilization and activation of phagocytic cells such as neutrophils and monocytes can result in muscular, vascular and systemic inflammation and oxidative stress due to the production of reactive oxygen species, these deleterious responses may be attenuated by the appropriate use of antioxidants and nutritional supplements. This review presents the findings from recent studies in the field of exercise immunology, and offers some insight into how these findings may be applied in the broad realm of preventive, complementary and alternative medicine.<br>

Journal

  • Japanese Journal of Complementary and Alternative Medicine

    Japanese Journal of Complementary and Alternative Medicine 1(1), 31-40, 2004

    The Japanese Society for Complementary and Alternative Medicine

Cited by:  3

Codes

  • NII Article ID (NAID)
    130000079428
  • NII NACSIS-CAT ID (NCID)
    AA12095429
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1348-7922
  • NDL Article ID
    7313657
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z74-E199
  • Data Source
    CJPref  NDL  J-STAGE 
Page Top