Mediastinal Seminoma in a Patient with Multiple Endocrine Neoplasia Type 1

DOI Web Site 13 References
  • Tanabe Tsuyoshi
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Yasuo Masanori
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Tsushima Kenji
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Urushihata Kazuhisa
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Yamamoto Hiroshi
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Hanaoka Masayuki
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Koizumi Tomonobu
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Fujimoto Keisaku
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • Yamazaki Yoshitaka
    Department of Endoscopy, Shinshu University School of Medicine
  • Hirose Yoshiki
    Department of Internal Medicine, Ina Chuo General Hospital
  • Hamano Hideaki
    The Second Department of Internal Medicine, Shinshu University School of Medicine
  • Sakurai Akihiro
    Division of Clinical and Molecular Genetics, Shinhu University Hospital
  • Kubo Keishi
    The First Department of Internal Medicine, Shinshu University School of Medicine

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Abstract

A patient with multiple endocrine neoplasia type 1 (MEN1) developed a mediastinal seminoma. The patient was a 46-year-old man who presented with respiratory symptoms. A diagnosis of mediastinal seminoma was pathologically confirmed and a complete remission was achieved by chemotherapy. During his hospital stay, hyperparathyroidism and multiple pancreatic tumors associated with hypergastrinemia were found. A diagnosis of MEN1 was made genetically. Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported. In addition, no etiological relationship between seminoma and MEN1 has yet been reported.<br>

Journal

  • Internal Medicine

    Internal Medicine 47 (18), 1615-1619, 2008

    The Japanese Society of Internal Medicine

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