Late Onset Neutropenia and Immunoglobulin Suppression of the Patients with Malignant Lymphoma Following Autologous Stem Cell Transplantation with Rituximab

DOI Web Site 被引用文献2件 参考文献8件
  • Hirayama Yasuo
    Department of Hematology and Oncology, Asahikawa Red Cross Hospital Department of Internal Medicine, Higashi Sapporo Hospital
  • Kohda Kyuhei
    Department of Hematology and Oncology, Asahikawa Red Cross Hospital
  • Konuma Yuichi
    Department of Hematology and Oncology, Asahikawa Red Cross Hospital
  • Hirata Yasuji
    Department of Internal Medicine, Hakodate Red Cross Hospital
  • Kuroda Hiroyuki
    Department of Hematology and Oncology, Asahikawa Red Cross Hospital Department of Internal Medicine, Higashi Sapporo Hospital
  • Fujimi Yuko
    The Fourth Department of Internal Medicine Sapporo Medical University
  • Shirao Sayaka
    The Fourth Department of Internal Medicine Sapporo Medical University
  • Kobune Masayoshi
    The Fourth Department of Internal Medicine Sapporo Medical University
  • Takimoto Rishu
    The Fourth Department of Internal Medicine Sapporo Medical University
  • Matsunaga Takuya
    The Fourth Department of Internal Medicine Sapporo Medical University
  • Kato Junji
    The Fourth Department of Internal Medicine Sapporo Medical University

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Background Recently, decrease of immunoglobulin concentrations or neutrophil counts were reported in some cases several months after administration of rituximab. We examined a number of episodes of late onset neutropenia or immunoglobulin decrease in patients with malignant lymphoma who were in complete remission following autologous transplantation with or without rituximab.<br> Method Patients with follicular lymphoma and diffuse large B cell lymphoma transplanted with or without rituximab in our institutes were analyzed. Immunoglobulin concentrations and neutrophil counts after transplantation, both with and without rituximab were measured serially.<br> Results Four weeks after transplantation, blood samples revealed lower concentrations of IgG and IgA in the rituximab group than in the non-rituximab group. Neutrophil numbers did not fall below 0.5×109 /L four weeks or more after transplantation in the non-rituximab group. Neutrophil numbers dropped below 0.5×109 /L in 6 of 14 cases in the rituximab group.<br> Conclusion Although the present study was retrospective and disease composition and pre-transplantation regimens differed between the two groups, the addition of rituximab to autologous transplantation might bring about a decrease of immunoglobulin levels and transient LON.<br>

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  • Internal Medicine

    Internal Medicine 48 (1), 57-60, 2009

    一般社団法人 日本内科学会

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