Physiological functions of protease-activated receptor-2.

DOI Web Site PubMed 3 Citations 134 References
  • KAWABATA Atsufumi
    Department of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University

Bibliographic Information

Other Title
  • プロテアーゼ受容体ＰＡＲ‐２（ｐｒｏｔｅａｓｅ‐ａｃｔｉｖａｔｅｄ　ｒｅｃｅｐｔｏｒ‐２）の生理機能
  • プロテアーゼ受容体PAR-2(protease-activated receptor-2)の生理機能
  • プロテアーゼ ジュヨウタイ PAR 2 protease activated receptor 2 ノ セイリ キノウ

Search this article

Abstract

Protease-activated receptors (PARs) are a family of G-protein-coupled-seven-trans-membrane-domain-receptors activated by specific proteases, consisting of four family members. PAR-2, a receptor activated by trypsin, tryptase or coagulation factors VIIa and Xa, is unevenly distributed throughout the mammalian body, modulating multiple physiological functions. In the gastrointestinal tract, PAR-2 is involved in gastric mucosal cytoprotection, smooth muscle motility modulation, salivary and pancreatic exocrine secretion, intestinal ionic transport, etc. In the circulatory system, endothelial PAR-2, upon activation, induces vascular relaxation by mechanisms dependent on nitric oxide or endothelium-derived hyperpolarizing factor (EDHF), resulting in hypotension in vivo. In the respiratory system, PAR-2 appears to play a dual role, being pro- and anti-inflammatory. In the nervous system, PAR-2 present in capsaicin-sensitive sensory neurons participates in processing of pain information. PAR-2 is thus involved in a variety of physiological and pathophysiological functions. PAR-2 is now considered one of the most important molecules as a target for drug development.<br>

Journal

Citations (3)*help

See more

References(134)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top