The proteasome: Overview of structure and functions

• TANAKA Keiji

  Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science

抄録

The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells. The highly organized proteasome plays a prominent role in the control of a diverse array of basic cellular activities by rapidly and unidirectionally catalyzing biological reactions. Studies of the proteasome during the past quarter of a century have provided profound insights into its structure and functions, which has appreciably contributed to our understanding of cellular life. Many questions, however, remain to be elucidated.<BR><BR>(Communicated by Takao SEKIYA, M.J.A.)

収録刊行物

• Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 85 (1), 12-36, 2009

  日本学士院

キーワード

• proteasome
• ubiquitin
• intracellular proteolysis
• multisubunit complex
• molecular chaperone

詳細情報

• CRID: 1390282679122512000
• NII論文ID: 130000093918
• NII書誌ID: AA00785485
• DOI: 10.2183/pjab.85.12
• COI: 1:STN:280:DC%2BD1M%2Fnt1Cluw%3D%3D
• ISSN: 13492896
• ISSN: 03862208
• ISSN: http://id.crossref.org/issn/13492896
• NDL書誌ID: 9778615
• PubMed: 19145068
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9778615
• Web Site: http://www.jstage.jst.go.jp/article/pjab/85/1/85_1_12/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009137755
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可